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Mmm Lithiated
So apparently 7Up was originally (1929) called "Bib-Label Lithiated Lemon-Lime Soda," because it contained lithium as its selling ingredient. This became "7Up Lithiated Lemon Soda," and then in 1936, simply "7Up."
The inventor, C.L. Grigg, never revealed how he chose the name "7Up", but I personally think it may have had something to do with imbibing a great deal of lithium citrate.